This study was undertaken in the pediatric population to evaluate the clinical efficacy and safety of celecoxib (Celebrex) capsules for pediatric inpatient and outpatient treatment for non-steroidal anti-inflammatory drugs (NSAIDs) in children with non-steroidal anti-inflammatory drugs (NSAIDs) use. This study was a prospective, open-label, randomized, parallel-group, 3-way crossover, single-dose crossover study. The primary objective was to determine the therapeutic effectiveness of celecoxib capsules in patients with non-steroidal anti-inflammatory drugs (NSAIDs) use.

Key words:Non-steroidal anti-inflammatory drugs (NSAIDs) - pediatric inpatient; pediatric outpatient; pediatric outpatient, non-steroidal anti-inflammatory drugs; NSAIDs - oral NSAIDs

Study Design and Design

This was a prospective, open-label, randomized, parallel-group, 3-way crossover study. Children with non-steroidal anti-inflammatory drugs (NSAIDs) use were included who were enrolled at an outpatient, pediatric inpatient, pediatric outpatient, and pediatric outpatient inpatient setting in the first 6 months of life.

Study Population

We included participants of the study who were diagnosed with non-steroidal anti-inflammatory drugs (NSAIDs) use in the last 12 months. They were excluded if they had:

• Known history of gastrointestinal bleeding, heart or gastrointestinal disease;
• Known or suspected asthma or allergic disorders;
• Known history of NSAID use.

We defined NSAID use as having a history of gastrointestinal bleeding or allergic reactions to aspirin, ibuprofen, aspirin acetate, or any of the other NSAIDs. Gastric acid was not used in any of the studies. We included patients who received at least one of the above medications within the past 12 months. We defined NSAID use as having a history of GI bleeding or allergic reactions to aspirin, ibuprofen, aspirin acetate, or any of the other NSAIDs.

Patients and Methods

We recruited pediatric patients with non-steroidal anti-inflammatory drugs (NSAIDs) use who were enrolled at an outpatient, pediatric inpatient, pediatric outpatient, and pediatric outpatient inpatient setting in the first 6 months of life, and were followed at every visit by a medical oncologist who conducted a 2-year post-approval follow-up. We included patients who were diagnosed with non-steroidal anti-inflammatory drugs (NSAIDs) use in the last 12 months, were followed for the first year of follow-up, and were followed for the following year.

We excluded patients who had a diagnosis of:

• Diagnostic testing of anemia or anemia with blood or urine tests or who had a history of bleeding or anemia prior to being enrolled in the study;
• History of GI bleeding or anemia or anemia after taking aspirin, ibuprofen, aspirin acetate, or any other NSAID, or had a history of NSAID use;
• History of NSAID use within the past 12 months;
• History of NSAID use after the last prescription of a nonsteroidal anti-inflammatory drug (NSAID) within the past 6 months;
• History of NSAID use within the past 6 months;
• History of NSAID use within the last 6 months; or
• Anemia or anemia within the past 6 months.

Baseline Patient Demographics and Follow-up

The primary endpoint was to assess the clinical efficacy and safety of celecoxib capsules in children with non-steroidal anti-inflammatory drugs (NSAIDs) use.

The secondary endpoint included the occurrence of adverse events.

Inclusion criteria were age <18 years. We excluded patients with:

• Known history of gastrointestinal bleeding or allergic reactions to aspirin, ibuprofen, aspirin acetate, or any of the other NSAIDs;
• Known history of NSAID use within the past 12 months;
• History of gastrointestinal bleeding or anemia or anemia;
• History of NSAID use within the past 6 months; or
• History of NSAID use within the last 6 months.

Statistical Analysis

We evaluated the sample size of the study using non-parametric and non-parametric statistical analyses.

Celebrex 100mg Tablet contains the active ingredient Celecoxib. It belongs to the family known as non-steroidal anti-inflammatory drugs (NSAID), and specifically a sub-group known as cyclooxygenase-2 (COX-2) inhibitors. It is used in adults for the relief of signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. In conditions like rheumatoid arthritis and osteoarthritis, excess production of prostaglandins by your body can lead to pain and inflammation. Celebrex 100mg Tablet works by decreasing the production of prostaglandins, effectively reducing pain and inflammation.

Do not take Celebrex 100mg Tablet if you are allergic to Celebrex 100mg Tablet or any of its ingredients. Inform your doctor if you had reactions to sulfonamide medicines, suffer from ulcers or bleeding in the stomach or intestines, or experienced adverse reactions to NSAID medications like aspirin.

Before starting the treatment, inform your doctor because it is recommended to not take this medicine if you are pregnant or are breastfeeding. Do not take this medicine if you have severe liver or kidney disease, have inflammatory intestinal conditions, or have heart-related issues such as heart failure, heart disease, or circulation problems. Additionally, if you have had surgeries on leg arteries or have a history of blood circulation problems, this medicine usage should be avoided. Celebrex 100mg Tablet contains lactose. If you are sugar intolerant, consult your doctor before using this product. This medicine is for adults only, it is not for use in children.

Inform your doctor about if you have a history of stomach or intestinal ulcers or bleeding (avoid if currently present), are on acetylsalicylic acid or antiplatelet therapies, use blood clotting or corticosteroid medications, or simultaneously use other non-acetylsalicylic NSAIDs like ibuprofen.

Report your doctor if you have conditions such as smoking, diabetes, high blood pressure, high cholesterol, compromised heart, liver, or kidney function, fluid retention, dehydration, past severe allergic reactions to medications, ongoing infections, or are over 65 years old. Monitoring may be necessary. Notably, Celebrex 100mg Tablet could mask fever or infection signs. Remember, alcohol combined with NSAIDs may increase gastrointestinal risks.

Show MoreCCelebrex 100mg Tablet is used to relieve signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is effective in the relief of joint pain, stiffness, and iliac pain. It is also used in cases of positive culture of a microorganism that causes infections in the blood. Celebrex 100mg Tablet is not recommended for use in children.Show MoreCifxx 100mg Tablet is used to relieve pain and inflammation in osteoarthritis, rheumatoid arthritis, and other conditions.Show MoreCifx 100mg Tablet is used to relieve pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.Show MoreCifx 100mg Tablet is used to relieve pain and inflammation in osteoarthritis, rheumatoid arthritis, and other conditions.

Sold and Supplied by Healthylife Pharmacy

Celebrex Celecoxib (100mg) 60 Capsules

This product is a Prescription Only Medicine (S4) and is sold by Healthylife Pharmacy, an independently owned and operated pharmacy business. This prescription product requires a valid Australian script.

Medicare CardNo MedicareConcession

$8.95

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HealthylifeHealth Information

Healthylife is notothal or any other medication retailer can legally sell prescription drugs without a prescription from a doctor. However, you may for a small fee, such as a small price point, if you have a health problem. If you require any information to ensure you have a medical reason to buy a prescription drug, just contact a health provider, use the drugarrassment function, or ask your health care provider for a suitable alternative. The prices listed below are exacted for the timeotopian brand Celebrex, and are not guaranteed. Healthylife does not sell or provide this drug for sale in the United States or other countries. If you are allergic to Celebrex, or if you have a severe or chronic heart problem (such as heart failure), stop taking Celebrex immediately and seek emergency medical attention. Stop taking Celebrex and contact your doctor if you experience sudden dizziness, fainting, shortness of breath or other signs of an allergic reaction. This drug may cause dizziness and fainting. Do not drive or do other hazardous activities, including operating machinery or doing heavy work because the risk of these effects increases because of the increased risk of drowsiness. This drug may increase your risk of seizures (convulsions) because of the increased risk of drowsiness. Do not take this drug if you have a history of heart problems, severe liver problems or serious blood disorders. This drug may increase your risk of priapism (abrasionated red blood cell death) because of the increased risk of dizziness or fainting. Do not take this drug if you are allergic to any other medications. If you are taking aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs), take special care in taking Celebrex, as it may increase the risk of serious or life-threatening side effects. If you have asthma, have high blood pressure, epilepsy or a seizure disorder, take special care with Celebrex, as it may cause serious or even life-threatening side effects (such as drowsiness, impaired vision, decreased hearing, muscle weakness, muscle inflammation, chest pain, rapid heartbeat, quick thinking, confusion, weakness in one part or side of body, slurred speech, pain in your jaw or throat, pain or tenderness in your stomach, dark-colored urine, pain when you take or drink coffee while taking this drug. Do not take this drug if you are taking aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) because these medications may decrease the effectiveness of this drug. If you have ever had an allergic reaction (rash, itching, swelling, difficulty breathing) to Celebrex, stop taking Celebrex and contact your doctor or pharmacist. If you experience any new or worsening symptoms while taking this drug, stop taking the drug and contact your doctor or pharmacist.

Health informationProduct information

Product name: 60 capsules (100mg) 60mg x 10

Pronunciation FUE-MOX-iDAL

Dr. Discussion

Brand: Celebrex 100mg

Pronunciation COD: 60-CA-BO-LE-eDAL-o-o-iDAL-a-o-i

Manufacturer: Healthylife

Country of Origin: United Kingdom

Strength: 60 mg/1.

How does the drug interact with Celebrex 200 mg Capsule:Taking eliglustat with Celebrex 200 mg Capsule can significantly increase the blood levels of eliglustat. This may increase the risk of serious side effects.How to manage the interaction:Taking Celebrex 200 mg Capsule with Eliglustat is not recommended, but can be taken together if prescribed by a doctor. However, consult the doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate and weak pulse. Do not discontinue any medications without consulting a doctor.

Co-administration of Cidofovir with Celebrex 200 mg Capsule can increase the risk of kidney problems.Taking Celebrex 200 mg Capsule with Cidofovir is not recommended, please consult your doctor before taking it. However, consult the doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to a doctor.

Taking thioridazine and Celebrex 200 mg Capsule may increases the blood levels of thioridazine which may cause irregular heart rhythm.Taking Celebrex 200 mg Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not stop using any medications without first talking to your doctor.

Co-administration of Celebrex 200 mg Capsule with Meloxicam can increase the risk or severity of bleeding and ulcers of the stomach lining leading to serious blood loss.Taking Meloxicam with Celebrex 200 mg Capsule is not recommended, but can be taken together if prescribed by a doctor. However, consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a dcovct

Taking Ketorolac with Celebrex 200 mg Capsule can increase the risk of side effects such as gastrointestinal bleeding and ulcers.Taking Celebrex 200 mg Capsule with Ketorolac is not recommended, but can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness.

CelecoxibKetorolac tromethamine

Taking Ketorolac with Celebrex 200 mg Capsule can increase the risk of gastrointestinal bleeding and ulcers,Taking Ketorolac tromethamine with Celebrex 200 mg Capsule is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness.

Tramadylene

Taking Ketorolac tromethamine with Celebrex 200 mg Capsule can increase the risk of gastrointestinal bleeding and ulcers,However, consult a doctor.